CIAICO/2022/008

«Efectos biológicos de rayos X y protones con tasas de dosis clínicas y ultra-altas», Grupos de Investigación Consolidados, Generalitat Valenciana, ref. CIAICO/2022/008. Collaborators: i3M (CSIC), Centro Nacional de Aceleradores, Universidade de Santiago de Compostela, Universidad de Salamanca.

The objective of the proposal is the study of radiobiological effects in living cells using two classes of radiation sources. On the one hand, protons and x-rays generated by ultra-intense laser pulses where the particles are concentrated at very short intervals, corresponding to ultra-high dose rates. And on the other hand, protons from an accelerator radio frequency with a constant intensity. These two extremes are of very high interest for new modalities of

external radiotherapy, especially the so-called Flash effect that, in recent years, has revealed the importance of dose rate as a key parameter for cancer treatment.

To achieve this objective, researchers from various disciplines have formed a stable group of excellence with the support of its scientific infrastructure. Their combined capabilities will allow advances in several frontier fields: the development of stable particle sources based on ultra-intense lasers, the application of these sources to the biomedical field, the precise measurement of radiation dose in ultra-short pulses, and the systematic and comparative study of cellular effects caused by different types of radiation.

Proyecto CIAICO/2022/008 financiado por Generalitat Valenciana en el programa Grupos de Investigación consolidados, 2023-25.